Multidisciplinary Head and Neck Cancer/Oral Oncology Program
V. Lalla, D.D.S., Ph.D., C.C.R.P.
Dr. Lalla is a board-certified clinician and scholar who
conducts clinical research on a variety of oral mucosal
disorders, including mucositis secondary to cancer treatment,
recurrent aphthous stomatitis (canker sores) and oral
candidiasis (thrush). His research has been funded by the
federal government (through the National Institutes of Health),
the American Cancer Society, the Donaghue Foundation, and
industry. In addition to clinical care and research, Dr. Lalla
is also involved in clinical and classroom teaching. He serves
on several institutional committees including as a Vice-Chair of
the Institutional Review Board (IRB), which oversees conduct of
clinical research, the Scientific Advisory Committee of the
Clinical Research Center, and the Strategic Planning Committee
of the School of Dental Medicine. Dr. Lalla holds several
leadership positions at the international level. He serves as
the Chair of the Mucositis Study Group of the Multinational
Association of Supportive Care in Cancer and the International
Society for Oral Oncology (MASCC/ISOO), as Chair of the MASCC
Guidelines Committee, and as a member of the MASCC Board of
Directors. Dr. Lalla has written more than 55 scientific
articles or book chapters, many of them dealing with oral
complications in cancer patients. He is also asked to speak on
oral complications of cancer therapy at the local and
international levels. He has reviewed articles written by others
for over 20 scientific journals. Dr. Lalla also serves as a
consultant on various topics including oral mucositis,
oropharyngeal candidiasis, recurrent aphthous stomatitis, and
clinical trial design and outcomes.
- Associate Professor with Tenure, Section of Oral
Medicine, University of Connecticut School of Dental
- Attending Staff, Department of Dentistry, John Dempsey
D.D.S., University of Bombay, India
Ph.D. in Biomedical Sciences, University of Connecticut Health
Oral Medicine, University
of Connecticut Health Center
Postdoctoral Fellowship Training
Clinical Research, University of Connecticut Health Center
Certified Clinical Research Professional (CCRP)
Diplomate of the American Board of Oral Medicine
- Head and Neck Cancer and Oral Oncology Program, Neag
Comprehensive Cancer Center
Honors and Awards
Best Scientific Paper: National level award at Indian
Dental Association Student Conference, 1994.
Graduate Fellowship: University of Connecticut,
Lester Burket Memorial Award: National level award from
the American Academy of Oral Medicine, 1999.
Travel Fellowship: to attend conference on Mucosal Injury
in Cancer Patients, 2000.
Edward H. Hatton Award: First Place, Senior Category.
National level research award from the American Association
of Dental Research (AADR), 2001. Selected to represent the
AADR at the international level competition.
Best Poster: 17th International Symposium of the
Multinational Association for Supportive Care in Cancer/
International Society for Oral Oncology (MASCC/ISOO), 2005.
Young Investigator Award: 17th International Symposium of
the Multinational Association for Supportive Care in Cancer/
International Society for Oral Oncology (MASCC/ISOO), 2005.
P.J. Robinson Award for Junior Faculty: Awarded in
recognition of significant scholarly research and teaching
Lalla RV, Peterson DE, Brennan MT and Schubert MM; Oral
Toxicity. In The Chemotherapy Sourcebook, 4th edition, edited by
Michael C. Perry. Lippincott Williams & Wilkins, Baltimore, MD,
Peterson DE and Lalla RV. Mucositis in Patients Receiving
Cancer Therapy. In Cancer Supportive Care: Advances in
Therapeutic Strategies. 1st Edition, edited by G. Lyman and J.
Crawford. Informa Healthcare, New York, NY, 2008.
Lalla RV and Peterson DE. Oral Symptoms. In Palliative
Medicine. 1st edition, edited by Declan Walsh. Elsevier,
Philadelphia, PA, 2008. 1st Spanish edition 2010.
Lalla RV. Oral Mucositis. (Invited monograph). British
Medical Journal Point-of-Care 2009. Tool for physicians and
other medical personnel. Available at
and at www.epocrates.com.
Peterson DE and Lalla RV. Overview of Complications of
Systemic Chemotherapy. In Oral Complications of Cancer and its
Management. 1st edition, edited by A. Davies and J. Epstein,
Oxford University Press, Oxford, UK, 2010.
Lalla RV, Brennan MT and Schubert MM. Oral Complications of
Cancer Therapy. In Pharmacology and Therapeutics for Dentistry,
6th edition, edited by J. Yagiela, F. Dowd, B. Johnson, A.
Mariotti and E. Neidle. Mosby/Elsevier, St. Louis, MO, 2010.
Lalla RV and Keefe DMK. Mucositis (oral and
gastrointestinal). In The MASCC Textbook of Cancer Supportive
Care and Survivorship, edited by I. Olver. Springer, NY. 2010.
Lalla RV. Fungal Infections. In Oral Complications of
Chemotherapy and Head/Neck Radiation, edited by D. Peterson.
National Cancer Institute PDQ Cancer Information Summaries
(Supportive Care). Published online March 24, 2011.
Brennan MT, Lalla RV, Schubert MM, and Peterson DE. Oral
Toxicity. In The Chemotherapy Sourcebook, 5th edition, edited by
Michael C. Perry, Donald C. Doll, and Carl E. Freter. Lippincott
Williams & Wilkins, Baltimore, MD, 2012.
Articles in Scientific Journals (Selected from 47
S. Sonis et al for the Mucositis Study Group (includes R
Lalla); Validation of a New Scoring System for Assessment of
Clinical Trials Research of Oral Mucositis Induced by Radiation
or Chemotherapy. Cancer, 85(10): 2103-2113, 1999.
Raber-Durlacher JE, Barasch A, Peterson DE, Lalla RV,
Schubert M, Fibbe WE. Oral Complications And Management
Considerations In Patients Treated With High-Dose Cancer
Chemotherapy. Supportive Cancer Therapy. 1(4):219-229, 2004.
Lalla RV and Peterson DE. Oral Mucositis. Dental Clinics of
North America, 49(1):167-184, 2005.
Lalla RV. Velafermin. Current Opinion in Investigational
Drugs, 6(11): 1179-1185, 2005. Also published in the online
Investigational Drugs Database.
Lalla RV, Schubert MM, Bensadoun RJ, Keefe D.
Anti-inflammatory agents in the management of alimentary
mucositis. Supportive Care in Cancer, 14(6):558-565, 2006.
Bensadoun RJ, Schubert MM, Lalla RV, Keefe D. Amifostine in
the management of radiation-induced and chemo-induced mucositis.
Supportive Care in Cancer. 14(6): 566-572, 2006.
Lalla RV and Peterson DE. Treatment of Mucositis - Including
New Medications. The Cancer Journal 12(5): 348-354, 2006.
Keefe DM et al; Mucositis Study Section (includes Lalla RV).
Updated clinical practice guidelines for the prevention and
treatment of mucositis. Cancer ; 109(5):820-31, 2007.
Lalla RV, Sonis ST, Peterson DE. Management of Oral Mucositis
in Patients Who Have Cancer. Dent Clin North Am, 52(1):61-77,
Lopes NNF, Plapler H, Chavantes MC, Lalla RV, Yoshimura EM,
Alves MTS. Cyclooxygenase-2 and vascular endothelial growth
factor expression in 5-fluorouracil-induced oral mucositis in
hamsters: evaluation of two low-intensity laser protocols.
Supportive Care in Cancer, 17(11):1409-15, 2009.
Lalla RV, Pilbeam CC, Walsh SJ, Sonis ST, Keefe DMK, Peterson
DE. Role of the Cyclooxygenase Pathway in Chemotherapy-induced
Oral Mucositis: A Pilot Study. Supportive Care in Cancer,
Lalla RV , Latortue MC, Hong CH, Ariyawardana A,
D’Amato-Palumbo S, Fischer D, Martof A, Nicolatou-Galitis
O, Patton L, Elting LS, Spijkervet FKL, Brennan MT. Fungal
Infections Section, Oral Care Study Group, Multinational
Association of Supportive Care in Cancer (MASCC)/International
Society of Oral Oncology (ISOO). A Systematic Review of Oral
Fungal Infections in Patients Receiving Cancer Therapy.
Supportive Care in Cancer,18(8):985-92, 2010.
Peterson DE and Lalla RV. Oral Mucositis: the New Paradigms.
Current Opinion in Oncology, 22(4):318-22, 2010.
Lopes NNF, Plapler H, Lalla RV, Chavantes MC, Yoshimura EM,
da Silva MAB, Alves MTS. Effects of Low Level Laser Therapy on
Collagen Expression and Neutrophil Infiltrate in
5-Fluorouracil-Induced Oral Mucositis in Hamsters. Lasers in
Surgery and Medicine, 42(6):546-552, 2010.
Lalla RV, Bensadoun RJ. Miconazole mucoadhesive tablet for
oropharyngeal candidiasis. Expert Reviews in Anti-Infective
Therapy, 9(1):13-17, 2011.
Bensadoun RJ, Patton LL, Lalla RV, Epstein JB. Oropharyngeal
candidiasis in head and neck cancer patients treated with
radiation: update 2011. Supportive Care in Cancer, 19(6):737-44,
Lalla RV. Translating Mucositis Research from Animal Models
to Humans. Journal of Supportive Oncology. 9(5):169, 2011.
View more publications, see
Oral complications of cancer therapy, oral mucosal disease
including oral mucositis, oropharyngeal candidiasis and
recurrent aphthous stomatitis.
Oral mucosal disease, including mucositis secondary to
cancer therapy, recurrent aphthous stomatitis and oral
Role of oral microorganisms in causing systemic
infections, in cancer patients with central venous catheters
and in patients with hemodialysis access devices.
At the UConn Health Center
On the Web