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Clinical Trials: Gynecological Cancers

Recurrent Disease - Cervical Cancer

Principal Investigator: Dr. Carolyn Runowicz

Title: A Phase II Study of Oxaliplatin in Combination with Paclitaxel in patients with Locally Recurrent or Metastatic Cervical Cancer

Description:. This Phase II study is testing a new chemotherapy regimen with Oxaliplatin and Paclitaxel for patients with locally recurrent or metastatic cancer of the cervix. This study is sponsored by the National Cancer Institute.

Length/Duration: Until disease progression

Compensation: None

Location: Neag Comprehensive Cancer Center at the University of Connecticut Health Center

For more information, patient benefits, and to learn if you qualify: please call 860-679-3066 or send an email to dnoel@uchc.edu

IRB#: 04-066

Sponsor: National Cancer Institute (NCI)

Screening - Ovarian Cancer

Principal Investigator: Dr. Carolyn Runowicz

Title: Collection of Clinical Samples from Patients at High Risk for Ovarian Cancer for Biomarker Studies

Description: The purpose of this study to determine the clinical utility of a panel of ovarian cancer markers to screen patients at high-risk for the development of ovarian cancer. This study will examine blood taken from patients with and without ovarian cancer and analyzed for the presence or absence of the identified markers.

Length/Duration: 1 hour

Compensation: None

Location: Neag Comprehensive Cancer Center at the University of Connecticut Health Center

For more information, patient benefits, and to learn if you qualify: please call 860-679-3066 or send an email to dnoel@uchc.edu

IRB #: 06-160

Sponsor: Tripath

Consolidation therapy - Ovarian Cancer

Principal Investigator: Dr. Zihai Li

Title: A Phase I study of tumor-derived Heat Shock Protein gp96, alone or in conjunction with GM-CSF, for the treatment of patients with Stage III and IV ovarian cancer after effective chemotherapy.

Description: This is for women that have successfully been treated with chemotherapeutics for ovarian cancer. The study aims to determine if treating these women with a vaccine will help to prevent the disease from recurring.

Length/Duration: 8 weeks of therapy followed by up to 2 years of follow-up

Compensation: None

Location: Neag Comprehensive Cancer Center at the University of Connecticut Health Center

For more information, patient benefits, and to learn if you qualify: please call 860-679-3066 or send an email to dnoel@uchc.edu

IRB #: 03-077

Sponsor: Investigator-initiated

Consolidation therapy - Ovarian Cancer

Principal Investigator: Dr. Carolyn Runowicz

Title: A Phase II Study of OSI 774 in Combination with Carboplatin and Paclitaxel in Patients with Ovarian, Cancer of the Fallopian Tube or Primary Peritoneal Carcinoma

Description: A phase II study of OSI 774 in combination with carboplatin and paclitaxel in patients with ovarian, cancer of the fallopian tube or primary peritoneal carcinoma

Length/Duration: Up to 1½ years of treatment

Compensation: None

Location: Neag Comprehensive Cancer Center at the University of Connecticut Health Center

For more information, patient benefits, and to learn if you qualify: please call 860-679-3066 or send an email to dnoel@uchc.edu

IRB #: 04-082

Sponsor: National Cancer Institute (NCI)

Second-line Therapy - Ovarian Cancer

Principal Investigator: Dr. Carolyn Runowicz

Title: Randomized study of TLK286 (Telcyta) in combination with Carboplatin (paraplatin) versus Liposomal Doxorubicin (Doxil) as second-line therapy in platinum refractory or resistant ovarian cancer

Description: This study will compare the effectiveness of an experimental compound (TLK286) in combination with Carbo/Taxel against liposomal doxorubicin (Doxil) for women with platinum refractory ovarian cancer. Women will be randomly placed into either group for their treatment.

Length/Duration: Patients will receive treatment every 4 weeks until either their disease progresses or they can no longer tolerate the treatment.

Compensation: None

Location: Neag Comprehensive Cancer Center at the University of Connecticut Health Center

For more information, patient benefits, and to learn if you qualify: please call 860-679-3066 or send an email to dnoel@uchc.edu

IRB #: 05-212

Sponsor: Telik, Inc.

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